26 December, 2008
Volume 135, Issue 7
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Volume 135, Issue 7
On the cover: Membrane fission is a regulated process during endocytosis and is dependent on the GTPase dynamin, which assembles at the necks of budded vesicles. In this issue, Pucadyil and Schmid (pp. 1263–1275) analyze dynamin behavior on membrane tubes pulled out of supported bilayers with excess reservoir (SUPER) on silica beads. The cover is a time-lapse sequence showing that in the presence of GTP, dynamin catalyzes multiple fission events, thereby fragmenting membrane tubes into small vesicles. Combined with analysis of dynamin distribution during fission, this study suggests that constant cycling of self-limited assemblies of dynamin generated in the presence of GTP is sufficient to catalyze membrane fission. See also the accompanying paper by Bashkirov et al. (pp. 1276–1286).
Most Read Papers
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- Proposed mechanism for DNA packaging by the T4 bacteriophage packaging motor.
- DNA (light blue) is pumped into the phage capsid (white) by the sequential tensing and relaxing of the five gp17 motor molecules (blue-green) around the vertex as they hydrolyze ATP. The model is based on structural and biochemical analysis of the motor. See paper by Sun et al. Movie directed by Petr Leiman (Purdue University), animation by Seyet LLC. You can also view a high resolution version.
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SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here, for a full list of SnapShots. The Human DNA Methylome in Health and Disease
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In this Issue
- Role of Ankyrin proteins in neuromuscular junction organization
- Uncovering a signaling network for necroptosis
- DHX29 promotes translation initiation of mRNAs with complex UTRs
- UV-Damage Recognition by DDB1-DDB2
- Silencing Splice Sites in Context
- Mechanism of membrane remodeling by Dynamin GTP hydrolysis: Pucadyil and Schmid and Bashkirov et al.
- Isolation of pluripotent rat embryonic stem cells: Buehr et al. and Li et al.
- A model for viral DNA packaging
- DNA demethylation in vertebrates in two steps
- Uncovering a signaling network for necroptosis
Featured Article
Featured articles are freely available to all readers
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Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5' Splice Site Competition Alternative splicing enables the production of multiple mRNA isoforms from a single pre-mRNA transcript and thus contributes significantly to the complexity of metazoans. This process can be regulated by motifs within the pre-mRNA. Using an in vitro selection approach, Yu et al. uncovered new silencing motifs which alter splice site choice without inactivating the affected site. The findings suggest that a small number of changes in a pre-mRNA which alter the kinetics of splicing could have dramatic consequences on splicing patterns. |
| In this PaperClip, Dr. Angela Andersen speaks with Dr. Tim Nilsen about his group's study which identifies new splice site silencers and provides insight into how alternative splice sites are chosen. |
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Cell Podcast
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In our latest podcast, we hear from Dr. Nathaniel Heintz about "TRAP," a new technique reported in Cell for looking at gene expression in the brain. Then we learn about a study in Current Biology from Dr. Robert Fleischer regarding the curious classification of the Hawaiian honeyeater. And we will also hear from Dr. Alan Beggs about his study in the American Journal of Human Genetics presenting a large-scale screen for mutations involved in Diamond-Blackfan anemia.
And stay tuned for a round-up of some of the exciting research advances recently published in Cell and the Cell Press family of journals. |
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Cell PaperClips
| In this PaperClip, Dr. Britta Mädge speaks with Dr. Jun-Yi Leu about his group’s identification of hybrid incompatibility genes in yeast.
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